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Human APEX2 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0227
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5" to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
APEX2
Synonyms
APEX2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; DNA-(apurinic or apyrimidinic site) lyase 2; APE2; APEXL2; XTH2; APEX nuclease 2; AP endonuclease 2; AP endonuclease XTH2; APEX nuclease-like 2; apurinic-apyrimidinic endonuclease 2; DNA-apurinic or apyrimidinic site lyase 2; apurinic/apyrimidinic endonuclease-like 2;
Gene ID
MIM
UniProt ID
Q9UBZ4
Chromosome Location
Xp11.23
Pathway
BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
Function
DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; endonuclease activity; exonuclease activity; hydrolase activity; lyase activity; metal ion binding; zinc ion binding;

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