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SARS-CoV-2 Related Cell Lines

The outbreaks of COVID-19 disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue worldwide. It poses life-threating to people's health and has raised global concerns. The current situation leads to the urgent tasks of drug discovery, vaccine development and diagnostic methods. As an international leading company, Creative Biogene is dedicated to providing scientific support for combating COVID-19.

Since the outbreak of the COVID-19, many efforts have been put on to perform related studies. Scientists have learned much about COVID-19 by using the different cell lines as the research tool. Studies have shown that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. Overexpression of human ACE2 enhanced disease severity that infected with SARS-CoV. With years of experience in engineered cell line generation, Creative Biogene is specializing in providing different kinds of overexpression and knockout cell lines for SARS-CoV-2 research. In addition, we also provide customized cell line service according to the specific needs.

The following is the details of available cell lines at Creative Biogene:

  • Engineered Cell Lines
Cat. No.Product NameCell Type
Overexpression Cell Lines
CSC-RO0292hACE2 Stable Cell Line - HEK293Human Embryonic Kidney-Derived Cell Line
CSC-RO0641hACE2 Stable Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RO0645hACE2 Stable Cell Line - VeroMonkey Kidney Cell Line
CSC-RO0646hACE2 Stable Cell Line - BHKHamster Kidney Fibroblast Cell Line
CSC-RO0289hACE2 Stable Cell Line - HeLaHuman Cervical Cancer Cell-Derived Cell Line
CSC-RO0291hACE2 Stable Cell Line – NIH-3T3Mouse Embryonic Fibroblast-Derived Cell Line
CSC-RO0293hACE2 Stable Cell Line - CHO-K1Chinese Hamster Ovary-Derived Cell Line
CSC-RO0642hACE2 Stable Cell Line - A549Human Lung Carcinoma-Derived Cell Line
CSC-RO0290hACE2 Stable Cell Line - COS7Monkey Kidney Fibroblast-Derived Cell Line
CSC-RO0643S Protein Stable Cell Line - CHOChinese Hamster Ovary-Derived Cell Line
CSC-RO0644S Protein Stable Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RO0647hACE2-GFP Stable Cell Line-HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RO0660Human ACE2/TMPRSS2 Stable Cell Line-HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RO0662TMPRSS2 Stable Cell Line-Vero E6Monkey Kidney Cell Line
Knockout (KO) Cell Lines
CSC-RT2688hACE2 KO Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RT2689TMPRSS2 KO Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RT2690hACE2 KO Cell Line - HEK293Human Embryonic Kidney-Derived Cell Line
CSC-RT2691TMPRSS2 KO Cell Line - HEK293Human Embryonic Kidney-Derived Cell Line
CSC-RT2692hACE2 KO Cell Line - HeLaHuman Cervical Cancer Cell-Derived Cell Line
CSC-RT2693TMPRSS2 KO Cell Line - HeLaHuman Cervical Cancer Cell-Derived Cell Line
  • SARS-CoV-2 Related Cell Lines
Cat.No.Product NameCell Type
Commonly Used Cell Lines for COVID-19 Research
CSC-C6236XA-549Human Lung Adenocarcinoma Cell Line
CSC-C2006BHK-21Hamster Kidney Fibroblast Cell Line
CSC-C3431HEK 293THuman Embryonic Kidney Cell Line
CSC-C9441LHUH7Human Liver Carcinoma Cell Line
CSC-C8867HMDCKMadin-Darby Canine Kidney Cell Line
CSC-C9580LPK-15Pig Kidney Cell Line
CSC-C8963HVEROMonkey Kidney Cell Line
CSC-C2768VERO-B4Monkey Kidney Cell Line
CSC-C9750LVERO 76Monkey Kidney Cell Line
CSC-C8227LU937Human Acute Monocytic Leukemia Cell Line
ACE2 Enhanced Cell Lines
CSC-C0487BEWOHuman Choriocarcinoma Cell Line
CSC-C8977HHaCaTImmortalized Human Keratinocyte Cell Line
CSC-C0313HepG2Human Hepatocellular Carcinoma Cell Line
CSC-C0328NB-4Human Acute Promyelocytic Leukemia Cell Line
CSC-C0447RPMI-8226Human Myeloma Cell Line
CSC-C0329SH-SY5YHuman Neuroblastoma Cell Line
TMPRSS2 Enhanced Cell Lines
CSC-C8200LCaco-2Human Epithelial Colorectal Adenocarcinoma Cell Line
CSC-C0262MCF-7Human Breast Cancer Cell Line
CSC-C8936HSK-BR-3Human Breast Cancer Cell Line
CSC-C2512T-47DHuman Breast Cancer Cell Line
ACE2 and TMPRSS2 Co-Enhanced Cell Line
CSC-C0455RT4Human Bladder Carcinoma Cell Line

In addition, we also provide cell line testing services according to your specific needs for SARS-CoV-2 research.

Features of Cell Lines at Creative Biogene

  • Multiple cell line types
  • Fast delivery time
  • Cost-effective
  • Customized cell line generation

There is no doubt Creative Biogene will be the best partner during your SARS-CoV-2 research. If you can't find what you want or want to know more information about SARS-CoV-2 related cell lines, please feel free to contact us.

Reference:

  1. Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T.S., Herrler, G., Wu, N.H., Nitsche, A., Müller, M.A., Drosten, C., Pöhlmann, S..(2020) SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181(2):271-280.
* For research use only. Not intended for any clinical use.
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