RFP

Official Full Name

tripartite motif containing 27

Organism

Homo sapiens

GeneID

5987

Background

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Synonyms

TRIM27; RFP; RNF76;

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Detailed Information

Fluorescent proteins (FPs) are powerful and specific marker tools for cellular imaging, and their range of applications is continuously expanding. Red fluorescent protein (RFP) is a versatile biological marker for visualizing protein localization, monitoring physiological processes, and detecting transgenic expression in vivo. RFP can be excited by the 488 nm or 532 nm laser line and is optimally detected at 588 nm. The creation of RFPs broadens the palette of fluorescent proteins making possible multicolor microscopy. The GFP-like mutant, recombinant RFPs developed recently differ from the wild-type precursors in the stability, quantum yield, the character of the absorption spectra, fluorescence excitation and emission.

An advantageous feature of the GFP-like proteins that can form chromophore without any co-factors other than molecular oxygen is their high stabilities. Besides, both N- and C-termini of fluorescent proteins are accessible for fusion, which allows coupling of a fluorescent protein with the target protein. The GFP-like proteins are generally non-toxic for cells. Compared to green proteins, the main advantage of RFPs is that the level of autofluorescence is much lower in the red spectral range and lesser scattering of the longer wavelength light.

Creative Biogene can help researchers save time and labor in generating and validating stable cell lines so scientists can spend more effort on solving the big questions. We now offer a variety of RFP stable cell lines that are easy to use as handy research tools - from optimizing your experimental conditions to validating any research experimental theories.

Features

Used to establish in vivo tumor models
Fully authenticated, versatile cell tools
Derived from commonly used human and mouse cell lines
Quantifiable RFP expression
Developed by single cell cloning

Creative Biogene can also provide custom reporter cell line generation service. Tell us about your project and we will be glad to help! Simply submit an overall description in the form below and a Creative Biogene representative and contact you shortly.

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