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LDLR


Official Full Name
low density lipoprotein receptor
Organism
Homo sapiens
Gene ID
3949
Background
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
Synonyms
FH; FHC; FHCL1; LDLCQ2

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SHH145533 shRNA set against Rat Ldlr(NM_175762.2) Inquiry
SHH329344 shRNA set against Rat LDLR (NM_175762.2) Inquiry
SHH329335 shRNA set against Human LDLR (NM_000527.4) Inquiry
SHH329339 shRNA set against Mouse LDLR (NM_010700.3) Inquiry
SHW004965 shRNA set against Chicken LDLR (NM_204452) Inquiry
Cat.No. Product Name Price
CDCL126663 Human LDLR ORF clone (NM_001195799.1) Inquiry
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MiUTR1R-02978 LDLR miRNA 3'UTR clone Inquiry
MiUTR3H-08845 LDLR miRNA 3'UTR clone Inquiry
CDCB157200 Mouse LDLR ORF clone (NM_010700.2) Inquiry
CDCB166440 Chicken LDLR ORF Clone (NM_204452) Inquiry
CDCB180785 Rabbit LDLR ORF clone (NM_001278865.1) Inquiry
CDCL126665 Human LDLR ORF clone (NM_001195803.1) Inquiry
CDCL126667 Mouse LDLR ORF clone (NM_001195798.1) Inquiry
CDCL126669 Mouse LDLR ORF clone (NM_001195800.1) Inquiry
CDCL126671 Human LDLR ORF clone (NM_001195802.1) Inquiry
CDCL151276 Mouse Ldlr ORF clone (NM_001252658.1) Inquiry
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