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GCH1


Official Full Name
GTP cyclohydrolase 1
Organism
Homo sapiens
Gene ID
2643
Background
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
Synonyms
GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1

Cat.No. Product Name Price
SHH300002 shRNA set against Mouse GCH1 (NM_008102.3) Inquiry
SHH079715 shRNA set against Human GCH1(NM_000161.2) Inquiry
SHH079733 shRNA set against Mouse Gch1(NM_008102.3) Inquiry
SHH079751 shRNA set against Human GCH1(NM_001024070.1) Inquiry
SHH079769 shRNA set against Human GCH1(NM_001024071.1) Inquiry
SHH299998 shRNA set against Human GCH1 (NM_000161.2) Inquiry
SHH300006 shRNA set against Rat GCH1 (NM_024356.1) Inquiry
SHW005719 shRNA set against Chicken GCH1 (NM_205223) Inquiry
SHW013096 shRNA set against Danio rerio GCH1 (NM_001136255) Inquiry
Cat.No. Product Name Price
CDCB167194 Chicken GCH1 ORF Clone (NM_205223) Inquiry
MiUTR1M-04975 GCH1 miRNA 3'UTR clone Inquiry
MiUTR1H-03983 GCH1 miRNA 3'UTR clone Inquiry
MiUTR1H-03982 GCH1 miRNA 3'UTR clone Inquiry
MiUTR1H-03981 GCH1 miRNA 3'UTR clone Inquiry
CDFR012301 Rat Gch1 cDNA Clone(NM_024356.1) Inquiry
CDFH007436 Human GCH1 cDNA Clone(NM_001024071.1) Inquiry
CDFH007435 Human GCH1 cDNA Clone(NM_001024070.1) Inquiry
CDFH007434 Human GCH1 cDNA Clone(NM_001024024.1) Inquiry
MiUTR1R-02060 GCH1 miRNA 3'UTR clone Inquiry
CDFH007433 Human GCH1 cDNA Clone(NM_000161.2) Inquiry
CDCL110997 Human GCH1 ORF clone (NM_001024070.1) Inquiry
CDFH007432 Human GCH1 cDNA Clone(NM_000161.2) Inquiry
MiUTR3H-03196 GCH1 miRNA 3'UTR clone Inquiry
CDCR379378 Rat Gch1 ORF Clone(NM_024356.1) Inquiry
CDCR342147 Human GCH1 ORF Clone(NM_001024071.1) Inquiry
CDCR342143 Human GCH1 ORF Clone(NM_001024024.1) Inquiry
CDCR278439 Human GCH1 ORF Clone(NM_000161.2) Inquiry
CDCL111001 Human Gch1 ORF clone (NM_008102.3) Inquiry
CDCB195395 Rabbit GCH1 ORF clone (XM_002718258.2) Inquiry
CDCB174571 Danio rerio GCH1 ORF Clone (NM_001136255) Inquiry
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