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ORC1


Official Full Name
origin recognition complex subunit 1
Organism
Homo sapiens
Gene ID
4998
Background
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Synonyms
ORC1L; PARC1; HSORC1

Cat.No. Product Name Price
SHH368404 shRNA set against Rat ORC1 (NM_177931.2) Inquiry
SHH364020 shRNA set against Rat Olr186 (NM_001001031.1) Inquiry
SHH368396 shRNA set against Human ORC1 (NM_004153.3) Inquiry
SHH368400 shRNA set against Mouse ORC1 (NM_011015.2) Inquiry
SHR059970 shRNA set against Rat Olr185_predicted(NM_001000183.1) Inquiry
SHR080538 shRNA set against Mouse Orc1l(NM_011015.2) Inquiry
SHR080632 shRNA set against Rat Orc1l(NM_177931.2) Inquiry
SHW001884 shRNA set against Chicken ORC1 (NM_001031286) Inquiry
SHW016186 shRNA set against Danio rerio ORC1 (NM_199933) Inquiry
Cat.No. Product Name Price
CDCR249937 Mouse Orc1 ORF Clone(NM_011015.2) Inquiry
CDFR000999 Rat Olr186 cDNA Clone(NM_001001031.1) Inquiry
CDFR014901 Rat Orc1 cDNA Clone(NM_177931.2) Inquiry
MiUTR1M-08742 ORC1 miRNA 3'UTR clone Inquiry
MiUTR1R-04943 OLR186 miRNA 3'UTR clone Inquiry
MiUTR1R-05553 ORC1 miRNA 3'UTR clone Inquiry
MiUTR4H-TG06325 ORC1 miRNA 3'UTR clone Inquiry
CDCB163359 Chicken ORC1 ORF Clone (NM_001031286) Inquiry
CDCB177661 Danio rerio ORC1 ORF Clone (NM_199933) Inquiry
CDCB188498 Rabbit ORC1 ORF clone (XM_008265251.1) Inquiry
CDCL144705 Mouse ORC1 ORF clone (NM_001190819.1) Inquiry
CDCR368086 Rat Olr186 ORF Clone(NM_001001031.1) Inquiry
CDCR381948 Rat Orc1 ORF Clone(NM_177931.2) Inquiry
CDCS409216 Human ORC1 ORF Clone (BC011539) Inquiry
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