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ELANE


Official Full Name
elastase, neutrophil expressed
Organism
Homo sapiens
Gene ID
1991
Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
Synonyms
GE; NE; HLE; HNE; ELA2; SCN1; PMN-E

Cat.No. Product Name Price
SHH284937 shRNA set against Human ELANE (NM_001972.2) Inquiry
SHH284941 shRNA set against Mouse ELANE (NM_015779.2) Inquiry
SHH284945 shRNA set against Rat ELANE (NM_001106767.1) Inquiry
Cat.No. Product Name Price
CDCR282013 Human ELANE ORF Clone(NM_001972.2) Inquiry
CDFH005831 Human ELANE cDNA Clone(NM_001972.2) Inquiry
CDFR006497 Rat Elane cDNA Clone(NM_001106767.1) Inquiry
MiUTR1M-04347 ELANE miRNA 3'UTR clone Inquiry
MiUTR3H-00699 ELANE miRNA 3'UTR clone Inquiry
CDCR373508 Rat Elane ORF Clone(NM_001106767.1) Inquiry
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