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VEGFA


Official Full Name
vascular endothelial growth factor A
Organism
Homo sapiens
Gene ID
7422
Background
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]
Synonyms
VPF; VEGF; MVCD1; L-VEGF

Cat.No. Product Name Price
SHL122724 shRNA set against Rat Vegfa(NM_031836.2) Inquiry
SHL125280 shRNA set against Mouse Vegfa(NM_001025250.3) Inquiry
SHL125316 shRNA set against Mouse Vegfa(NM_001110268.1) Inquiry
SHH442572 shRNA set against Human VEGFA (NM_003376.5) Inquiry
SHH442580 shRNA set against Rat VEGFA (NM_031836.2) Inquiry
SHL122368 shRNA set against Human VEGFA(NM_001171630.1) Inquiry
SHL122652 shRNA set against Mouse Vegfa(NM_001025257.3) Inquiry
SHL125182 shRNA set against Mouse Vegfa(NM_001110268.1) Inquiry
SHW002713 shRNA set against Chicken VEGFA (NM_001110355) Inquiry
SHW005542 shRNA set against Chicken VEGFA (NM_205042) Inquiry
Cat.No. Product Name Price
CDCB156479 Rat VEGFA ORF clone (AY033506.1) Inquiry
CDFH021062 Human VEGFA cDNA Clone(NM_001171623.1) Inquiry
CDFH021063 Human VEGFA cDNA Clone(NM_001171625.1) Inquiry
CDFH021064 Human VEGFA cDNA Clone(NM_001171626.1) Inquiry
CDFH021065 Human VEGFA cDNA Clone(NM_001171627.1) Inquiry
CDFH021066 Human VEGFA cDNA Clone(NM_001171628.1) Inquiry
CDFH021067 Human VEGFA cDNA Clone(NM_001171629.1) Inquiry
CDFH021068 Human VEGFA cDNA Clone(NM_001171630.1) Inquiry
CDFL014824 Mouse Vegfa cDNA Clone(NM_009505.4) Inquiry
CDFR009248 Rat Vegfa cDNA Clone(NM_001110333.1) Inquiry
CDFR009249 Rat Vegfa cDNA Clone(NM_001110334.1) Inquiry
CDFR009250 Rat Vegfa cDNA Clone(NM_001110335.1) Inquiry
CDFH021061 Human VEGFA cDNA Clone(NM_001171624.1) Inquiry
CDFR009251 Rat Vegfa cDNA Clone(NM_001110336.1) Inquiry
MiUTR1H-11112 VEGFA miRNA 3'UTR clone Inquiry
MiUTR1M-12674 VEGFA miRNA 3'UTR clone Inquiry
MiUTR1M-12675 VEGFA miRNA 3'UTR clone Inquiry
MiUTR1M-12676 VEGFA miRNA 3'UTR clone Inquiry
MiUTR1M-12677 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02397 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02398 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02399 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02400 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02401 VEGFA miRNA 3'UTR clone Inquiry
MiUTR3H-02402 VEGFA miRNA 3'UTR clone Inquiry
CDFR012965 Rat Vegfa cDNA Clone(NM_031836.2) Inquiry
CDFH021060 Human VEGFA cDNA Clone(NM_001171622.1) Inquiry
CDFG018990 Mouse Vegfa cDNA Clone(NM_001110267.1) Inquiry
CDFG017967 Mouse Vegfa cDNA Clone(NM_001110268.1) Inquiry
CDCH099382 Mouse Vegfa ORF clone (NM_001110267.1) Inquiry
CDCH099384 Mouse Vegfa ORF clone (NM_001110266.1) Inquiry
CDCH099386 Mouse Vegfa ORF clone (NM_009505.4) Inquiry
CDCH099396 Mouse Vegfa ORF clone (NM_001025250.3) Inquiry
CDCR342479 Human VEGFA ORF Clone(NM_001025367.2) Inquiry
MiUTR3H-02403 VEGFA miRNA 3'UTR clone Inquiry
CDCR356123 Human VEGFA ORF Clone(NM_001171627.1) Inquiry
CDCR356128 Human VEGFA ORF Clone(NM_001171629.1) Inquiry
SKO0933 VEGFA Validated sgRNA vector Inquiry
CDFG017462 Mouse Vegfa cDNA Clone(NM_001025250.3) Inquiry
CDCR376297 Rat Vegfa ORF Clone(NM_001110335.1) Inquiry
CDCR376298 Rat Vegfa ORF Clone(NM_001110336.1) Inquiry
CDCS406704 Human VEGFA ORF Clone (BC065522) Inquiry
CDFG017513 Mouse Vegfa cDNA Clone(NM_001025257.3) Inquiry
CDFG017966 Mouse Vegfa cDNA Clone(NM_001110266.1) Inquiry
CDCB156950 Canine VEGFA ORF clone (AF133248.1) Inquiry
CDCB164188 Chicken VEGFA ORF Clone (NM_001110355) Inquiry
CDCB167017 Chicken VEGFA ORF Clone (NM_205042) Inquiry
CDCH099376 human VEGFA ORF clone (NM_001171622.1) Inquiry
CDCH099380 Mouse Vegfa ORF clone (NM_001110268.1) Inquiry
CDCR356129 Human VEGFA ORF Clone(NM_001171630.1) Inquiry
CDCL186719 Human VEGFA ORF clone(NM_001171626.1) Inquiry
CDCR285351 Human VEGFA ORF Clone(NM_003376.5) Inquiry
CDCR379979 Rat Vegfa ORF Clone(NM_031836.2) Inquiry
CDCR376296 Rat Vegfa ORF Clone(NM_001110334.1) Inquiry
CDCR376295 Rat Vegfa ORF Clone(NM_001110333.1) Inquiry
CDCR356115 Human VEGFA ORF Clone(NM_001171623.1) Inquiry
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