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PRKAR1A


Official Full Name
protein kinase cAMP-dependent type I regulatory subunit alpha
Organism
Homo sapiens
Gene ID
5573
Background
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Synonyms
CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1; Prkar1alpha

Cat.No. Product Name Price
SHG186353 shRNA set against Human PRKAR1A(NM_002734.3) Inquiry
SHH382732 shRNA set against Human PRKAR1A (NM_002734.3) Inquiry
SHH382736 shRNA set against Mouse PRKAR1A (NM_021880.2) Inquiry
SHH382740 shRNA set against Rat PRKAR1A (NM_013181.1) Inquiry
SHR139956 shRNA set against Rat Prkar1a(NM_013181.1) Inquiry
SHR139998 shRNA set against Mouse Prkar1a(NM_021880.2) Inquiry
SHW000712 shRNA set against Chicken PRKAR1A (NM_001007845) Inquiry
Cat.No. Product Name Price
CDFG013905 Human PRKAR1A cDNA Clone(NM_212471.1) Inquiry
MiUTR1M-09573 PRKAR1A miRNA 3'UTR clone Inquiry
MiUTR1H-08267 PRKAR1A miRNA 3'UTR clone Inquiry
CDFR011021 Rat Prkar1a cDNA Clone(NM_013181.1) Inquiry
CDFH015105 Human PRKAR1A cDNA Clone(NM_002734.3) Inquiry
CDFH015104 Human PRKAR1A cDNA Clone(NM_002734.3) Inquiry
CDFG013909 Human PRKAR1A cDNA Clone(NM_212472.1) Inquiry
MiUTR1R-06051 PRKAR1A miRNA 3'UTR clone Inquiry
SKO0707 PRKAR1A Validated sgRNA vector Inquiry
CDCR378014 Rat Prkar1a ORF Clone(NM_013181.1) Inquiry
CDCR328266 Human PRKAR1A ORF Clone(NM_212472.1) Inquiry
CDCR328264 Human PRKAR1A ORF Clone(NM_212471.1) Inquiry
CDCR283920 Human PRKAR1A ORF Clone(NM_002734.3) Inquiry
CDCB181093 Rabbit PRKAR1A ORF clone (XM_002719492.2) Inquiry
CDCB162187 Chicken PRKAR1A ORF Clone (NM_001007845) Inquiry
CDCS410927 Human PRKAR1A ORF Clone (BC036285) Inquiry
CDCB158960 Human PRKAR1A ORF clone (BC036285) Inquiry
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