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PTTG1


Official Full Name
PTTG1 regulator of sister chromatid separation, securin
Organism
Homo sapiens
Gene ID
9232
Background
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Synonyms
EAP1; PTTG; ECRAR; HPTTG; TUTR1

Cat.No. Product Name Price
SHH386960 shRNA set against Mouse PTTG1 (NM_013917.2) Inquiry
SHR154446 shRNA set against Mouse Pttg1(NM_001131054.1) Inquiry
SHR154464 shRNA set against Human PTTG1(NM_004219.2) Inquiry
SHW004052 shRNA set against Chicken PTTG1 (NM_001277741) Inquiry
SHH386956 shRNA set against Human PTTG1 (NM_004219.2) Inquiry
SHH386964 shRNA set against Rat PTTG1 (NM_022391.2) Inquiry
SHR154410 shRNA set against Rat Pttg1(NM_022391.2) Inquiry
SHW004051 shRNA set against Chicken PTTG1 (NM_001277740) Inquiry
SHW014151 shRNA set against Danio rerio PTTG1 (NM_001271474) Inquiry
Cat.No. Product Name Price
CDCB184261 Rabbit PTTG1 ORF clone (XM_008255352.1) Inquiry
CDCH070054 Mouse Pttg1 ORF clone (NM_001131054.1) Inquiry
CDFG019491 Mouse Pttg1 cDNA Clone(NM_001131054.1) Inquiry
CDFH015609 Human PTTG1 cDNA Clone(NM_004219.2) Inquiry
CDFL011074 Mouse Pttg1 cDNA Clone(NM_013917.2) Inquiry
CDFR011840 Rat Pttg1 cDNA Clone(NM_022391.2) Inquiry
MiUTR1H-08487 PTTG1 miRNA 3'UTR clone Inquiry
MiUTR1M-09788 PTTG1 miRNA 3'UTR clone Inquiry
MiUTR1R-06218 PTTG1 miRNA 3'UTR clone Inquiry
SKO0730 PTTG1 Validated sgRNA vector Inquiry
CDCB165526 Chicken PTTG1 ORF Clone (NM_001277740) Inquiry
CDCB165527 Chicken PTTG1 ORF Clone (NM_001277741) Inquiry
CDCB175626 Danio rerio PTTG1 ORF Clone (NM_001271474) Inquiry
CDCR252651 Mouse Pttg1 ORF Clone(NM_013917.2) Inquiry
CDCR378999 Rat Pttg1 ORF Clone(NM_022391.2) Inquiry
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