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LIG4


Official Full Name
DNA ligase 4
Organism
Homo sapiens
Gene ID
3981
Background
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Synonyms
LIG4S

Cat.No. Product Name Price
SHH149357 shRNA set against Mouse Lig4(NM_176953.3) Inquiry
SHH330251 shRNA set against Human LIG4 (NM_002312.3) Inquiry
SHH149339 shRNA set against Human LIG4(NM_002312.3) Inquiry
SHH330255 shRNA set against Mouse LIG4 (NM_176953.3) Inquiry
SHH330259 shRNA set against Rat LIG4 (NM_001106095.1) Inquiry
SHW001455 shRNA set against Chicken LIG4 (NM_001030816) Inquiry
SHW011846 shRNA set against Danio rerio LIG4 (NM_001103123) Inquiry
Cat.No. Product Name Price
CDCB158954 Human LIG4 ORF clone (BC037491) Inquiry
MiUTR1M-06644 LIG4 miRNA 3'UTR clone Inquiry
MiUTR1H-05669 LIG4 miRNA 3'UTR clone Inquiry
CDFR005677 Rat Lig4 cDNA Clone(NM_001106095.1) Inquiry
CDFL006957 Mouse Lig4 cDNA Clone(NM_176953.3) Inquiry
CDFH010374 Human LIG4 cDNA Clone(NM_002312.3) Inquiry
CDFH010373 Human LIG4 cDNA Clone(NM_001098268.1) Inquiry
CDFG013689 Human LIG4 cDNA Clone(NM_206937.1) Inquiry
MiUTR3H-04444 LIG4 miRNA 3'UTR clone Inquiry
MiUTR3H-04446 LIG4 miRNA 3'UTR clone Inquiry
CDCR282937 Human LIG4 ORF Clone(NM_002312.3) Inquiry
CDCL127195 Mouse Lig4 ORF clone (NM_176953.3) Inquiry
CDCB162930 Chicken LIG4 ORF Clone (NM_001030816) Inquiry
CDCR346452 Human LIG4 ORF Clone(NM_001098268.1) Inquiry
CDCR327720 Human LIG4 ORF Clone(NM_206937.1) Inquiry
CDCB193451 Rabbit LIG4 ORF clone (XM_008260172.1) Inquiry
CDCB173321 Danio rerio LIG4 ORF Clone (NM_001103123) Inquiry
CDCR372557 Rat Lig4 ORF Clone(NM_001106095.1) Inquiry
CDCS407408 Human LIG4 ORF Clone (BC037491) Inquiry
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