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HMGCR


Official Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Organism
Homo sapiens
Gene ID
3156
Background
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Synonyms
MYPLG; LDLCQ3; LGMDR28

Cat.No. Product Name Price
SHH313381 shRNA set against Rat HMGCR (NM_013134.2) Inquiry
SHH125345 shRNA set against Rat Hmgcr(NM_013134.2) Inquiry
SHH125377 shRNA set against Mouse Hmgcr(NM_008255.2) Inquiry
SHH313373 shRNA set against Human HMGCR (NM_000859.2) Inquiry
SHH313377 shRNA set against Mouse HMGCR (NM_008255.2) Inquiry
SHW004998 shRNA set against Chicken HMGCR (NM_204485) Inquiry
Cat.No. Product Name Price
CDCR377980 Rat Hmgcr ORF Clone(NM_013134.2) Inquiry
CDFH008620 Human HMGCR cDNA Clone(NM_001130996.1) Inquiry
CDFR010933 Rat Hmgcr cDNA Clone(NM_013134.2) Inquiry
MiUTR1M-05700 HMGCR miRNA 3'UTR clone Inquiry
MiUTR1R-02451 HMGCR miRNA 3'UTR clone Inquiry
MiUTR3H-01092 HMGCR miRNA 3'UTR clone Inquiry
MiUTR3H-01093 HMGCR miRNA 3'UTR clone Inquiry
CDCB166473 Chicken HMGCR ORF Clone (NM_204485) Inquiry
CDCB183231 Rabbit HMGCR ORF clone (XM_008251139.1) Inquiry
CDCR006077 Mouse HMGCR ORF clone(NM_008255.2) Inquiry
CDCR349801 Human HMGCR ORF Clone(NM_001130996.1) Inquiry
CDCS405956 Human HMGCR ORF Clone (BC033692) Inquiry
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