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GCLC


Official Full Name
glutamate-cysteine ligase catalytic subunit
Organism
Homo sapiens
Gene ID
2729
Background
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Synonyms
GCL; GCS; GLCL; GLCLC; CNSHA7

Cat.No. Product Name Price
SHH300050 shRNA set against Mouse GCLC (NM_010295.2) Inquiry
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SHH300054 shRNA set against Rat GCLC (NM_012815.2) Inquiry
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Cat.No. Product Name Price
CDCL111025 Human GCLC ORF clone (NM_001197115.1) Inquiry
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CDCB177270 Danio rerio GCLC ORF Clone (NM_199277) Inquiry
CDCB192259 Rabbit GCLC ORF clone (XM_002714508.2) Inquiry
CDCR377675 Rat Gclc ORF Clone(NM_012815.2) Inquiry
CDCS409351 Human GCLC ORF Clone (BC022487) Inquiry
CDCS409352 Human GCLC ORF Clone (BC039894) Inquiry
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