Pages
Products

DIO2


Official Full Name
iodothyronine deiodinase 2
Organism
Homo sapiens
Gene ID
1734
Background
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the non-standard amino acid, selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Unlike the other two members (DIO1 and DIO3) of this enzyme family, the mRNA for this gene contains an additional in-frame UGA codon that has been reported (in human) to function either as a Sec or a stop codon, which can result in two isoforms with one or two Sec residues; however, only the upstream Sec (conserved with the single Sec residue found at the active site in DIO1 and DIO3) was shown to be essential for enzyme activity (PMID:10403186). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2018]
Synonyms
D2; 5DII; SelY; DIOII; TXDI2; SELENOY

Cat.No. Product Name Price
SHH005609 shRNA set against Mouse Dio2(NM_010050.2) Inquiry
SHH278125 shRNA set against Mouse DIO2 (NM_010050.2) Inquiry
SHH278129 shRNA set against Rat DIO2 (NM_031720.3) Inquiry
SHW017942 shRNA set against Danio rerio DIO2 (NM_212789) Inquiry
SHH005555 shRNA set against Rat Dio2(NM_031720.3) Inquiry
SHH278121 shRNA set against Human DIO2 (NM_000793.5) Inquiry
SHW004633 shRNA set against Chicken DIO2 (NM_204114) Inquiry
Cat.No. Product Name Price
CDCB179417 Danio rerio DIO2 ORF Clone (NM_212789) Inquiry
CDCB185396 Rabbit DIO2 ORF clone (NM_001256300.1) Inquiry
CDCR055602 Human DIO2 ORF clone (NM_001242503.1) Inquiry
CDFR012856 Rat Dio2 cDNA Clone(NM_031720.3) Inquiry
MiUTR1M-03867 DIO2 miRNA 3'UTR clone Inquiry
MiUTR1R-01495 DIO2 miRNA 3'UTR clone Inquiry
CDCB166108 Chicken DIO2 ORF Clone (NM_204114) Inquiry
CDCR055600 Human DIO2 ORF clone (NM_001242502.1) Inquiry
CDCR247823 Mouse Dio2 ORF Clone(NM_010050.2) Inquiry
CDCR379870 Rat Dio2 ORF Clone(NM_031720.3) Inquiry
Quick Inquiry