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CBFB


Official Full Name
core-binding factor subunit beta
Organism
Homo sapiens
Gene ID
865
Background
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CLCD2; PEBP2B

Cat.No. Product Name Price
SHG143983 shRNA set against Rat Cbfb(NM_001013191.1) Inquiry
SHG144235 shRNA set against Human CBFB(NM_001755.2) Inquiry
SHG144253 shRNA set against Human CBFB(NM_022845.2) Inquiry
SHH255289 shRNA set against Human CBFB (NM_001755.2) Inquiry
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Cat.No. Product Name Price
CDCR041942 Human CBFB ORF clone (NM_001755.2) Inquiry
CDCR308279 Human CBFB ORF Clone(NM_022845.2) Inquiry
CDCR369952 Rat Cbfb ORF Clone(NM_001013191.1) Inquiry
CDFG004004 Human CBFB cDNA Clone(NM_022845.2) Inquiry
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CDCB177254 Danio rerio CBFB ORF Clone (NM_199209) Inquiry
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CDCR041946 Mouse Cbfb ORF clone (NM_001161456.1) Inquiry
CDCR041948 Mouse Cbfb ORF clone (NM_001161457.1) Inquiry
CDCR041950 Mouse Cbfb ORF clone (NM_001161458.1) Inquiry
CDCS410417 Human CBFB ORF Clone (BC018509) Inquiry
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