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CDKN2A


Official Full Name
cyclin dependent kinase inhibitor 2A
Organism
Homo sapiens
Gene ID
1029
Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Synonyms
ARF; MLM; P14; P16; P19; CAI2; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

Cat.No. Product Name Price
SHG165273 shRNA set against Rat Cdkn2a(NM_031550.1) Inquiry
SHH260845 shRNA set against Human CDKN2A (NM_000077.4) Inquiry
SHH260849 shRNA set against Mouse CDKN2A (NM_009877.2) Inquiry
SHG165409 shRNA set against Mouse Cdkn2a(NM_001040654.1) Inquiry
SHG165445 shRNA set against Mouse Cdkn2a(NM_009877.2) Inquiry
SHH260853 shRNA set against Rat CDKN2A (NM_031550.1) Inquiry
SHW004947 shRNA set against Chicken CDKN2A (NM_204434) Inquiry
Cat.No. Product Name Price
CDCB166422 Chicken CDKN2A ORF Clone (NM_204434) Inquiry
CDCR006006 Human CDKN2A ORF clone(NM_000077.4) Inquiry
CDCR045392 Human CDKN2A ORF clone (NM_058195.3) Inquiry
CDCR045522 Mouse Cdkn2a ORF clone (NM_001040654.1) Inquiry
CDFR012708 Rat Cdkn2a cDNA Clone(NM_031550.1) Inquiry
MiUTR1M-02880 CDKN2A miRNA 3'UTR clone Inquiry
MiUTR1R-00917 CDKN2A miRNA 3'UTR clone Inquiry
MiUTR4H-TG01959 CDKN2A miRNA 3'UTR clone Inquiry
SKO0375 CDKN2A Validated sgRNA vector Inquiry
CDCB193255 Rabbit CDKN2A ORF clone (XM_008253055.1) Inquiry
CDCR045394 Human CDKN2A ORF clone (NM_001195132.1) Inquiry
CDCR045524 Mouse Cdkn2a ORF clone (NM_009877.2) Inquiry
CDCR314786 Human CDKN2A ORF Clone(NM_058197.4) Inquiry
CDCR379741 Rat Cdkn2a ORF Clone(NM_031550.1) Inquiry
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