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APH1A


Official Full Name
aph-1 homolog A, gamma-secretase subunit
Organism
Homo sapiens
Gene ID
51107
Background
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Synonyms
APH-1; APH-1A; CGI-78; 6530402N02Rik

Cat.No. Product Name Price
SHG064565 shRNA set against Rat Aph1a(NM_001014255.1) Inquiry
SHG064639 shRNA set against Mouse Aph1a(NM_146104.2) Inquiry
SHH238198 shRNA set against Human APH1A (NM_016022.3) Inquiry
SHH238202 shRNA set against Mouse APH1A (NM_146104.2) Inquiry
SHH238206 shRNA set against Rat APH1A (NM_001014255.1) Inquiry
Cat.No. Product Name Price
CDCR268056 Mouse Aph1a ORF Clone(NM_146134.1) Inquiry
CDCS407239 Human APH1A ORF Clone (BC001230) Inquiry
CDCS407240 Human APH1A ORF Clone (BC015568) Inquiry
CDFR003364 Rat Aph1a cDNA Clone(NM_001014255.1) Inquiry
MiUTR1M-01569 APH1A miRNA 3'UTR clone Inquiry
MiUTR1R-00299 APH1A miRNA 3'UTR clone Inquiry
MiUTR3H-09353 APH1A miRNA 3'UTR clone Inquiry
MiUTR3H-09354 APH1A miRNA 3'UTR clone Inquiry
CDCB189694 Rabbit MARCH3 ORF clone (XM_008254970.1) Inquiry
CDCB192353 Rabbit APH1A ORF clone (XM_002715601.2) Inquiry
CDCR028762 Human APH1A ORF clone (NM_001243771.1) Inquiry
CDCR028764 Human APH1A ORF clone (NM_001243772.1) Inquiry
CDCR268007 Mouse Aph1a ORF Clone(NM_146104.2) Inquiry
CDCR370383 Rat Aph1a ORF Clone(NM_001014255.1) Inquiry
CDCS407238 Human APH1A ORF Clone (BC008732) Inquiry
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