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UGT1A1


Official Full Name
UDP glucuronosyltransferase family 1 member A1
Organism
Homo sapiens
Gene ID
54658
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
Synonyms
GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1

Cat.No. Product Name Price
SHH440048 shRNA set against Human UGT1A1 (NM_000463.2) Inquiry
SHH440052 shRNA set against Mouse UGT1A1 (NM_201645.2) Inquiry
SHH440056 shRNA set against Rat UGT1A1 (NM_012683.2) Inquiry
SHL105642 shRNA set against Human UGT1A1(NM_000463.2) Inquiry
SHL112806 shRNA set against Rat Ugt1a1(NM_012683.2) Inquiry
SHW009427 shRNA set against Danio rerio UGT1A1 (NM_001037428) Inquiry
Cat.No. Product Name Price
CDFH020824 Human UGT1A1 cDNA Clone(NM_000463.2) Inquiry
CDFL014655 Mouse Ugt1a1 cDNA Clone(NM_201645.2) Inquiry
CDFR010498 Rat Ugt1a1 cDNA Clone(NM_012683.2) Inquiry
MiUTR1H-10988 UGT1A1 miRNA 3'UTR clone Inquiry
MiUTR1R-08337 UGT1A1 miRNA 3'UTR clone Inquiry
CDCB170902 Danio rerio UGT1A1 ORF Clone (NM_001037428) Inquiry
CDCL186677 Human UGT1A1 ORF clone(NM_000463.2) Inquiry
CDCR277077 Mouse Ugt1a1 ORF Clone(NM_201645.2) Inquiry
CDCR377545 Rat Ugt1a1 ORF Clone(NM_012683.2) Inquiry
CDCS405676 Human UGT1A1 ORF Clone (BC128415) Inquiry
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