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TOP2A


Official Full Name
DNA topoisomerase II alpha
Organism
Homo sapiens
Gene ID
7153
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Synonyms
TOP2; TP2A; TOPIIA; TOP2alpha

Cat.No. Product Name Price
SHH432860 shRNA set against Human TOP2A (NM_001067.3) Inquiry
SHH432864 shRNA set against Mouse TOP2A (NM_011623.2) Inquiry
SHL087596 shRNA set against Rat Top2a(NM_022183.2) Inquiry
SHW005297 shRNA set against Chicken TOP2A (NM_204791) Inquiry
SHW007011 shRNA set against Danio rerio TOP2A (NM_001003834) Inquiry
Cat.No. Product Name Price
CDFL014154 Mouse Top2a cDNA Clone(NM_011623.2) Inquiry
CDFR011816 Rat Top2a cDNA Clone(NM_022183.2) Inquiry
MiUTR1M-12049 TOP2A miRNA 3'UTR clone Inquiry
MiUTR1R-08151 TOP2A miRNA 3'UTR clone Inquiry
MiUTR3H-00685 TOP2A miRNA 3'UTR clone Inquiry
CDCB166772 Chicken TOP2A ORF Clone (NM_204791) Inquiry
CDCB168486 Danio rerio TOP2A ORF Clone (NM_001003834) Inquiry
CDCB183297 Rabbit TOP2A ORF clone (XM_008271788.1) Inquiry
CDCR250868 Mouse Top2a ORF Clone(NM_011623.2) Inquiry
CDCR378874 Rat Top2a ORF Clone(NM_022183.2) Inquiry
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