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SHH


Official Full Name
sonic hedgehog signaling molecule
Organism
Homo sapiens
Gene ID
6469
Background
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
Synonyms
TPT; HHG1; HLP3; HPE3; SMMCI; ShhNC; TPTPS; MCOPCB5

Cat.No. Product Name Price
SHR224282 shRNA set against Human SHH(NM_000193.2) Inquiry
SHR224300 shRNA set against Mouse Shh(NM_009170.3) Inquiry
SHH407056 shRNA set against Human SHH (NM_000193.2) Inquiry
SHH407060 shRNA set against Mouse SHH (NM_009170.3) Inquiry
SHR224214 shRNA set against Rat Shh(NM_017221.1) Inquiry
SHW005327 shRNA set against Chicken SHH (NM_204821) Inquiry
SHW014577 shRNA set against Danio rerio SHHA (NM_131063) Inquiry
Cat.No. Product Name Price
CDCB166802 Chicken SHH ORF Clone (NM_204821) Inquiry
CDCR378285 Rat Shh ORF Clone(NM_017221.1) Inquiry
CDFH017514 Human SHH cDNA Clone(NM_000193.2) Inquiry
CDFR006681 Rat RGD1563104 cDNA Clone(NM_001106967.1) Inquiry
CDFR011271 Rat Shh cDNA Clone(NM_017221.1) Inquiry
MiUTR1H-09380 SHH miRNA 3'UTR clone Inquiry
MiUTR1M-10686 SHH miRNA 3'UTR clone Inquiry
MiUTR1R-07338 SHH miRNA 3'UTR clone Inquiry
CDCB176052 Danio rerio SHHA ORF Clone (NM_131063) Inquiry
CDCB186231 Rabbit SHH ORF clone (XM_002715022.2) Inquiry
CDCL186178 Mouse SHH ORF clone(NM_009170.3) Inquiry
CDCR373743 Rat RGD1563104 ORF Clone(NM_001106967.1) Inquiry
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