Pages
Products

SKP2


Official Full Name
S-phase kinase associated protein 2
Organism
Homo sapiens
Gene ID
6502
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Synonyms
p45; FBL1; FLB1; FBXL1

Cat.No. Product Name Price
SHR193164 shRNA set against Human SKP2(NM_005983.3) Inquiry
SHR193260 shRNA set against Mouse Skp2(NM_145468.1) Inquiry
SHR193332 shRNA set against Mouse Skp2(NM_013787.2) Inquiry
SHW000761 shRNA set against Chicken SKP2 (NM_001007982) Inquiry
SHW011119 shRNA set against Danio rerio SKP2 (NM_001082837) Inquiry
Cat.No. Product Name Price
CDCB158451 Human SKP2 ORF clone (BC001441) Inquiry
CDCR373215 Rat Skp2 ORF Clone(NM_001106416.2) Inquiry
CDFL012351 Mouse Skp2 cDNA Clone(NM_145468.1) Inquiry
CDFR006152 Rat Skp2 cDNA Clone(NM_001106416.2) Inquiry
MiUTR1M-10727 SKP2 miRNA 3'UTR clone Inquiry
MiUTR3H-04118 SKP2 miRNA 3'UTR clone Inquiry
MiUTR3H-04119 SKP2 miRNA 3'UTR clone Inquiry
CDCB162236 Chicken SKP2 ORF Clone (NM_001007982) Inquiry
CDCB172594 Danio rerio SKP2 ORF Clone (NM_001082837) Inquiry
CDCB192217 Rabbit SKP2 ORF clone (XM_002713966.2) Inquiry
CDCH080614 human SKP2 ORF clone (NM_001243120.1) Inquiry
CDCH080616 Mouse Skp2 ORF clone (NM_013787.2) Inquiry
CDCH080618 Mouse Skp2 ORF clone (NM_145468.1) Inquiry
CDCS409834 Human SKP2 ORF Clone (BC001441) Inquiry
Quick Inquiry