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SIVA1

Official Full Name
SIVA1 apoptosis inducing factor
Organism
Homo sapiens
GeneID
10572
Background
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Synonyms
SIVA; CD27BP; Siva-1; Siva-2;

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