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SCN11A


Official Full Name
sodium voltage-gated channel alpha subunit 11
Organism
Homo sapiens
Gene ID
11280
Background
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Synonyms
NaN; PN5; FEPS3; HSAN7; SNS-2; NAV1.9; SCN12A

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SHR207902 shRNA set against Rat Scn11a(NM_019265.2) Inquiry
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CDFL011977 Mouse Scn11a cDNA Clone(NM_011887.3) Inquiry
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MiUTR1H-09179 SCN11A miRNA 3'UTR clone Inquiry
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