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PTGS2

Official Full Name
prostaglandin-endoperoxide synthase 2
Organism
Homo sapiens
GeneID
5743
Background
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Synonyms
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS;

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