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PSEN2


Official Full Name
presenilin 2
Organism
Homo sapiens
Gene ID
5664
Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Synonyms
AD4; PS2; AD3L; STM2; CMD1V

Cat.No. Product Name Price
SHH384872 shRNA set against Human PSEN2 (NM_000447.2) Inquiry
SHH384876 shRNA set against Mouse PSEN2 (NM_011183.3) Inquiry
SHH384880 shRNA set against Rat PSEN2 (NM_031087.2) Inquiry
SHR146310 shRNA set against Human PSEN2(NM_012486.2) Inquiry
SHR146328 shRNA set against Human PSEN2(NM_000447.2) Inquiry
SHR146346 shRNA set against Rat Psen2(NM_031087.2) Inquiry
SHW004818 shRNA set against Chicken PSEN2 (NM_204302) Inquiry
SHW014949 shRNA set against Danio rerio PSEN2 (NM_131514) Inquiry
Cat.No. Product Name Price
CDCR237300 Mouse Psen2 ORF Clone(NM_001128605.1) Inquiry
CDFR012558 Rat Psen2 cDNA Clone(NM_031087.2) Inquiry
MiUTR1H-08361 PSEN2 miRNA 3'UTR clone Inquiry
MiUTR1H-08362 PSEN2 miRNA 3'UTR clone Inquiry
MiUTR1R-06130 PSEN2 miRNA 3'UTR clone Inquiry
CDCB166293 Chicken PSEN2 ORF Clone (NM_204302) Inquiry
CDCB176424 Danio rerio PSEN2 ORF Clone (NM_131514) Inquiry
CDCB191520 Rabbit PSEN2 ORF clone (XM_008268146.1) Inquiry
CDCH068828 human PSEN2 ORF clone (NM_012486.2) Inquiry
CDCH395609 Mouse PSEN2 ORF clone(NM_011183.3) Inquiry
CDCR379580 Rat Psen2 ORF Clone(NM_031087.2) Inquiry
CDCS405667 Human PSEN2 ORF Clone (BC006365) Inquiry
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