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PDHA1


Official Full Name
pyruvate dehydrogenase E1 subunit alpha 1
Organism
Homo sapiens
Gene ID
5160
Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Synonyms
PDHA; PDHAD; PHE1A; E1alpha; PDHCE1A

Cat.No. Product Name Price
AD12026Z Human PDHA1 adenoviral particles Inquiry
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SHH372724 shRNA set against Mouse PDHA1 (NM_008810.2) Inquiry
SHH372728 shRNA set against Rat PDHA1 (NM_001004072.2) Inquiry
SHR101758 shRNA set against Mouse Pdha1(NM_008810.2) Inquiry
SHR101814 shRNA set against Rat Pdha1(NM_001004072.2) Inquiry
SHW000860 shRNA set against Chicken PDHA1 (NM_001012544) Inquiry
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CDCL147599 Human PDHA1 ORF clone (NM_001173455.1) Inquiry
CDCL147603 Mouse Pdha1 ORF clone (NM_008810.2) Inquiry
CDCR368313 Rat Pdha1 ORF Clone(NM_001004072.2) Inquiry
CDFH013976 Human PDHA1 cDNA Clone(NM_001173454.1) Inquiry
CDFH013977 Human PDHA1 cDNA Clone(NM_001173455.1) Inquiry
CDFH013978 Human PDHA1 cDNA Clone(NM_001173456.1) Inquiry
CDFR001276 Rat Pdha1 cDNA Clone(NM_001004072.2) Inquiry
MiUTR1M-09066 PDHA1 miRNA 3'UTR clone Inquiry
MiUTR1R-05727 PDHA1 miRNA 3'UTR clone Inquiry
SKO0251 PDHA1 Validated sgRNA vector Inquiry
CDCB162335 Chicken PDHA1 ORF Clone (NM_001012544) Inquiry
CDCB183501 Rabbit PDHA1 ORF clone (XM_002719941.2) Inquiry
CDCL147597 Human PDHA1 ORF clone (NM_001173456.1) Inquiry
CDCL147601 Human PDHA1 ORF clone (NM_001173454.1) Inquiry
CDCS405547 Human PDHA1 ORF Clone (BC002406) Inquiry
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