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PSTPIP1


Official Full Name
proline-serine-threonine phosphatase interacting protein 1
Organism
Homo sapiens
Gene ID
9051
Background
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
Synonyms
PAPA; AICZC; H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S

Cat.No. Product Name Price
SHH385712 shRNA set against Human PSTPIP1 (NM_003978.3) Inquiry
SHH385716 shRNA set against Mouse PSTPIP1 (NM_011193.2) Inquiry
SHH385720 shRNA set against Rat PSTPIP1 (NM_001106824.2) Inquiry
Cat.No. Product Name Price
CDCR250263 Mouse Pstpip1 ORF Clone(NM_011193.2) Inquiry
CDFR006552 Rat Pstpip1 cDNA Clone(NM_001106824.2) Inquiry
MiUTR3H-08385 PSTPIP1 miRNA 3'UTR clone Inquiry
CDCB182219 Rabbit PSTPIP1 ORF clone (XM_008249184.1) Inquiry
CDCR373562 Rat Pstpip1 ORF Clone(NM_001106824.2) Inquiry
CDCS411568 Human PSTPIP1 ORF Clone (BC008602) Inquiry
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