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PRKG1


Official Full Name
protein kinase cGMP-dependent 1
Organism
Homo sapiens
Gene ID
5592
Background
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Synonyms
PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha

Cat.No. Product Name Price
SHH382960 shRNA set against Human Prkg1 (NM_006258.3) Inquiry
SHH382964 shRNA set against Mouse Prkg1 (NM_011160.3) Inquiry
SHH382968 shRNA set against Rat Prkg1 (NM_001105731.2) Inquiry
Cat.No. Product Name Price
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CDFR005466 Rat Prkg1 cDNA Clone(NM_001105731.2) Inquiry
MiUTR3H-01903 PRKG1 miRNA 3'UTR clone Inquiry
MiUTR3H-01904 PRKG1 miRNA 3'UTR clone Inquiry
CDCB180552 Rabbit PRKG1 ORF clone (XM_008269904.1) Inquiry
CDCL224353 Mouse Prkg1 ORF Clone(NM_001013833.3) Inquiry
CDCR250196 Mouse Prkg1 ORF Clone(NM_011160.3) Inquiry
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