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PLOD1

Official Full Name
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Organism
Homo sapiens
GeneID
5351
Background
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Synonyms
LH; LH1; LLH; EDS6; PLOD; EDSKCL1;

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