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PLAT


Official Full Name
plasminogen activator, tissue type
Organism
Homo sapiens
Gene ID
5327
Background
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Synonyms
TPA; T-PA

Cat.No. Product Name Price
SHH377036 shRNA set against Human PLAT (NM_000930.3) Inquiry
SHH377040 shRNA set against Mouse PLAT (NM_008872.2) Inquiry
SHH377045 shRNA set against Rat PLAT (NM_013151.2) Inquiry
SHR119832 shRNA set against Human PLAT(NM_033011.2) Inquiry
SHR119842 shRNA set against Human PLAT(NM_000930.3) Inquiry
SHR119864 shRNA set against Human PLAT(NM_033011.2) Inquiry
SHR119918 shRNA set against Rat Plat(NM_013151.2) Inquiry
Cat.No. Product Name Price
CDCL185742 Mouse PLAT ORF clone(NM_008872.2) Inquiry
CDCS406000 Human PLAT ORF Clone (BC007231) Inquiry
CDFR010948 Rat Plat cDNA Clone(NM_013151.2) Inquiry
MiUTR1H-07974 PLAT miRNA 3'UTR clone Inquiry
MiUTR1H-07975 PLAT miRNA 3'UTR clone Inquiry
MiUTR1R-05888 PLAT miRNA 3'UTR clone Inquiry
CDCB180952 Rabbit PLAT ORF clone (NM_001082769.1) Inquiry
CDCR378025 Rat Plat ORF Clone(NM_013151.2) Inquiry
Cat.No. Product Name Price
CC-1088 PLAT Easy KO Kit Inquiry
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