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NCSTN


Official Full Name
nicastrin
Organism
Homo sapiens
Gene ID
23385
Background
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Synonyms
ATAG1874

Cat.No. Product Name Price
SHH350240 shRNA set against Human NCSTN (NM_015331.2) Inquiry
SHH350244 shRNA set against Mouse NCSTN (NM_021607.3) Inquiry
SHH350248 shRNA set against Rat NCSTN (NM_174864.3) Inquiry
SHR001542 shRNA set against Rat Ncstn(NM_174864.3) Inquiry
SHR003486 shRNA set against Human NCSTN(NM_015331.2) Inquiry
SHW000173 shRNA set against Chicken NCSTN (NM_001004413) Inquiry
SHW007832 shRNA set against Danio rerio NCSTN (NM_001009556) Inquiry
Cat.No. Product Name Price
CDCS413930 Human NCSTN ORF Clone (BC047621) Inquiry
CDFH012284 Human NCSTN cDNA Clone(NM_015331.2) Inquiry
CDFR014832 Rat Ncstn cDNA Clone(NM_174864.3) Inquiry
MiUTR1H-06690 NCSTN miRNA 3'UTR clone Inquiry
MiUTR1R-04139 NCSTN miRNA 3'UTR clone Inquiry
SKO1100 NCSTN Validated sgRNA vector Inquiry
CDCB161648 Chicken NCSTN ORF Clone (NM_001004413) Inquiry
CDCB169307 Danio rerio NCSTN ORF Clone (NM_001009556) Inquiry
CDCB190913 Rabbit NCSTN ORF clone (XM_008264222.1) Inquiry
CDCL185440 Human NCSTN ORF clone(NM_015331.2) Inquiry
CDCL185442 Mouse NCSTN ORF clone(NM_021607.3) Inquiry
CDCR381749 Rat Ncstn ORF Clone(NM_174864.3) Inquiry
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