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MAP3K11

Official Full Name
mitogen-activated protein kinase kinase kinase 11
Organism
Homo sapiens
GeneID
4296
Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Synonyms
MLK3; PTK1; SPRK; MLK-3; MEKK11;

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