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IREB2


Official Full Name
iron responsive element binding protein 2
Organism
Homo sapiens
Gene ID
3658
Background
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Synonyms
ACO3; IRP2; IRP2AD; NDCAMA; IRE-BP2; IRE-BP 2

Cat.No. Product Name Price
SHH320545 shRNA set against Human IREB2 (NM_004136.2) Inquiry
SHH320549 shRNA set against Mouse IREB2 (NM_022655.3) Inquiry
SHH320553 shRNA set against Rat IREB2 (NM_022863.2) Inquiry
SHL173478 shRNA set against Rat Ireb2(NM_022863.2) Inquiry
SHL173496 shRNA set against Human IREB2(NM_004136.2) Inquiry
SHW002043 shRNA set against Chicken IREB2 (NM_001031454) Inquiry
Cat.No. Product Name Price
CDCR379184 Rat Ireb2 ORF Clone(NM_022863.2) Inquiry
CDFR012137 Rat Ireb2 cDNA Clone(NM_022863.2) Inquiry
MiUTR1H-04989 IREB2 miRNA 3'UTR clone Inquiry
MiUTR1R-02689 IREB2 miRNA 3'UTR clone Inquiry
CDCB163518 Chicken IREB2 ORF Clone (NM_001031454) Inquiry
CDCB192539 Rabbit IREB2 ORF clone (XM_008248447.1) Inquiry
CDCL121553 Mouse IREB2 ORF clone (NM_004136.2) Inquiry
CDCR255517 Mouse Ireb2 ORF Clone(NM_022655.3) Inquiry
CDCS411632 Human IREB2 ORF Clone (BC017880) Inquiry
CDCS411633 Human IREB2 ORF Clone (BC117481) Inquiry
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