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HEXB


Official Full Name
hexosaminidase subunit beta
Organism
Homo sapiens
Gene ID
3074
Background
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Synonyms
ENC-1AS; HEL-248; HEL-S-111

Cat.No. Product Name Price
SHH311781 shRNA set against Mouse HEXB (NM_010422.2) Inquiry
SHH311777 shRNA set against Human HEXB (NM_000521.3) Inquiry
SHH311785 shRNA set against Rat HEXB (NM_001011946.1) Inquiry
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CDFL005647 Mouse Hexb cDNA Clone(NM_010422.2) Inquiry
CDFR002375 Rat Hexb cDNA Clone(NM_001011946.1) Inquiry
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MiUTR3H-08789 HEXB miRNA 3'UTR clone Inquiry
CDCB180955 Rabbit HEXB ORF clone (XM_002721124.2) Inquiry
CDCR248967 Mouse Hexb ORF Clone(NM_010422.2) Inquiry
CDCR369463 Rat Hexb ORF Clone(NM_001011946.1) Inquiry
CDCS405720 Human HEXB ORF Clone (BC017378) Inquiry
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