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ERN1


Official Full Name
endoplasmic reticulum to nucleus signaling 1
Organism
Homo sapiens
Gene ID
2081
Background
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Synonyms
IRE1; IRE1P; IRE1a; hIRE1p

Cat.No. Product Name Price
SHH039017 shRNA set against Human ERN1(NM_001433.3) Inquiry
SHW004410 shRNA set against Chicken ERN1 (NM_001285501) Inquiry
SHW008610 shRNA set against Danio rerio ERN1 (NM_001020530) Inquiry
SHH039035 shRNA set against Mouse Ern1(NM_023913.2) Inquiry
SHH287181 shRNA set against Human ERN1 (NM_001433.3) Inquiry
SHH287185 shRNA set against Mouse ERN1 (NM_023913.2) Inquiry
Cat.No. Product Name Price
CDFL004218 Mouse Ern1 cDNA Clone(NM_023913.2) Inquiry
MiUTR1H-03302 ERN1 miRNA 3'UTR clone Inquiry
MiUTR1M-04469 ERN1 miRNA 3'UTR clone Inquiry
CDCB165885 Chicken ERN1 ORF Clone (NM_001285501) Inquiry
CDCB170085 Danio rerio ERN1 ORF Clone (NM_001020530) Inquiry
CDCB183504 Rabbit ERN1 ORF clone (XM_008271709.1) Inquiry
CDCR061256 Human ERN1 ORF clone (NM_001433.3) Inquiry
CDCR061258 Mouse Ern1 ORF clone (NM_023913.2) Inquiry
CDCS410273 Human ERN1 ORF Clone (BC130405) Inquiry
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