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ERG


Official Full Name
ETS transcription factor ERG
Organism
Homo sapiens
Gene ID
2078
Background
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Synonyms
p55; erg-3; LMPHM14

Cat.No. Product Name Price
SHH038567 shRNA set against Rat Erg(NM_133397.1) Inquiry
SHH038603 shRNA set against Human ERG(NM_001136154.1) Inquiry
SHH038621 shRNA set against Mouse Erg(NM_133659.2) Inquiry
SHH287001 shRNA set against Human ERG (NM_182918.3) Inquiry
SHH287005 shRNA set against Mouse ERG (NM_133659.2) Inquiry
SHH287009 shRNA set against Rat ERG (NM_133397.1) Inquiry
SHW004796 shRNA set against Chicken ERG (NM_204280) Inquiry
SHW007792 shRNA set against Danio rerio ERG (NM_001008616) Inquiry
Cat.No. Product Name Price
CDCB166271 Chicken ERG ORF Clone (NM_204280) Inquiry
CDFH006070 Human ERG cDNA Clone(NM_001136154.1) Inquiry
CDFH006071 Human ERG cDNA Clone(NM_001136155.1) Inquiry
CDFR014010 Rat Erg cDNA Clone(NM_133397.1) Inquiry
MiUTR1H-03294 ERG miRNA 3'UTR clone Inquiry
MiUTR1M-04465 ERG miRNA 3'UTR clone Inquiry
MiUTR1R-01767 ERG miRNA 3'UTR clone Inquiry
MiUTR4H-TG03147 ERG miRNA 3'UTR clone Inquiry
CDCB169267 Danio rerio ERG ORF Clone (NM_001008616) Inquiry
CDCB189445 Rabbit ERG ORF clone (XM_008274887.1) Inquiry
CDCR061152 Mouse Erg ORF clone (NM_133659.2) Inquiry
CDCR061156 Human ERG ORF clone (NM_001243432.1) Inquiry
CDCR061158 Human ERG ORF clone (NM_001136154.1) Inquiry
CDCR061160 Human ERG ORF clone (NM_001136155.1) Inquiry
CDCR381024 Rat Erg ORF Clone(NM_133397.1) Inquiry
CDCS408177 Human ERG ORF Clone (BC040168) Inquiry
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