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EGLN1


Official Full Name
egl-9 family hypoxia inducible factor 1
Organism
Homo sapiens
Gene ID
54583
Background
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
Synonyms
HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2

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SHH027065 shRNA set against Mouse Egln1(NM_053207.2) Inquiry
SHH027081 shRNA set against Human EGLN1(NM_022051.2) Inquiry
SHH283865 shRNA set against Human EGLN1 (NM_022051.2) Inquiry
SHH283869 shRNA set against Mouse EGLN1 (NM_053207.2) Inquiry
SHW006598 shRNA set against Danio rerio EGLN1B (NM_001002595) Inquiry
Cat.No. Product Name Price
MiUTR1H-03140 EGLN1 miRNA 3'UTR clone Inquiry
MiUTR1M-04290 EGLN1 miRNA 3'UTR clone Inquiry
CDCB168073 Danio rerio EGLN1B ORF Clone (NM_001002595) Inquiry
CDCB183513 Rabbit EGLN1 ORF clone (XM_002717333.2) Inquiry
CDCR059172 Mouse Egln1 ORF clone (NM_053207.2) Inquiry
CDCS415417 Human EGLN1 ORF Clone (BC005369) Inquiry
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