Pages
Products

DOCK2


Official Full Name
dedicator of cytokinesis 2
Organism
Homo sapiens
Gene ID
1794
Background
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]
Synonyms
IMD40

Cat.No. Product Name Price
SHH280169 shRNA set against Human DOCK2 (NM_004946.2) Inquiry
SHH013187 shRNA set against Mouse Dock2(NM_033374.2) Inquiry
SHH280173 shRNA set against Mouse DOCK2 (NM_033374.2) Inquiry
Cat.No. Product Name Price
CDFL003763 Mouse Dock2 cDNA Clone(NM_033374.2) Inquiry
MiUTR1M-03956 DOCK2 miRNA 3'UTR clone Inquiry
MiUTR3H-05686 DOCK2 miRNA 3'UTR clone Inquiry
CDCB183536 Rabbit DOCK2 ORF clone (XM_008255434.1) Inquiry
CDCR056838 Mouse Dock2 ORF clone (NM_033374.2) Inquiry
CDCS412033 Human DOCK2 ORF Clone (BC113457) Inquiry
Quick Inquiry