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COL18A1


Official Full Name
collagen type XVIII alpha 1 chain
Organism
Homo sapiens
Gene ID
80781
Background
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Synonyms
KS; KNO; GLCC; KNO1

Cat.No. Product Name Price
SHW004682 shRNA set against Chicken COL18A1 (NM_204164) Inquiry
SHG189699 shRNA set against Mouse Col18a1(NM_001109991.1) Inquiry
SHG189717 shRNA set against Mouse Col18a1(NM_009929.3) Inquiry
SHG189735 shRNA set against Human COL18A1(NM_130445.2) Inquiry
SHG189753 shRNA set against Human COL18A1(NM_030582.3) Inquiry
SHH267113 shRNA set against Human COL18A1 (NM_030582.3) Inquiry
SHH267117 shRNA set against Mouse COL18A1 (NM_009929.3) Inquiry
SHW009520 shRNA set against Danio rerio COL18A1 (NM_001039630) Inquiry
Cat.No. Product Name Price
CDCB170995 Danio rerio COL18A1 ORF Clone (NM_001039630) Inquiry
CDCH383700 Rat COL18A1 ORF clone(NM_053489.2) Inquiry
CDCR247800 Mouse Col18a1 ORF Clone(NM_009929.3) Inquiry
MiUTR1H-02307 COL18A1 miRNA 3'UTR clone Inquiry
MiUTR1H-02308 COL18A1 miRNA 3'UTR clone Inquiry
MiUTR1M-03195 COL18A1 miRNA 3'UTR clone Inquiry
CDCB166157 Chicken COL18A1 ORF Clone (NM_204164) Inquiry
CDCB181940 Rabbit COL18A1 ORF clone (XM_008253234.1) Inquiry
CDCR049236 Human COL18A1 ORF clone (NM_030582.3) Inquiry
CDCR049244 Mouse Col18a1 ORF clone (NM_001109991.1) Inquiry
CDCR315467 Human COL18A1 ORF Clone(NM_130445.2) Inquiry
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