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CDKN1C


Official Full Name
cyclin dependent kinase inhibitor 1C
Organism
Homo sapiens
Gene ID
1028
Background
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Synonyms
BWS; WBS; p57; BWCR; KIP2; p57Kip2

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