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COCH


Official Full Name
cochlin
Organism
Homo sapiens
Gene ID
1690
Background
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
Synonyms
DFNA9; COCH5B2; DFNB110; COCH-5B2

Cat.No. Product Name Price
SHH266885 shRNA set against Human COCH (NM_004086.2) Inquiry
SHH266893 shRNA set against Rat COCH (NM_001108710.1) Inquiry
SHW005440 shRNA set against Chicken COCH (NM_204937) Inquiry
SHW007005 shRNA set against Danio rerio COCH (NM_001003823) Inquiry
Cat.No. Product Name Price
CDCR350211 Human COCH ORF Clone(NM_001135058.1) Inquiry
CDCS408047 Human COCH ORF Clone (BC007230) Inquiry
CDFG022045 Mouse Coch cDNA Clone(BC045137) Inquiry
CDFH004003 Human COCH cDNA Clone(NM_001135058.1) Inquiry
CDFR008298 Rat Coch cDNA Clone(NM_001108710.1) Inquiry
MiUTR3H-05767 COCH miRNA 3'UTR clone Inquiry
MiUTR3H-05768 COCH miRNA 3'UTR clone Inquiry
CDCB166915 Chicken COCH ORF Clone (NM_204937) Inquiry
CDCB168480 Danio rerio COCH ORF Clone (NM_001003823) Inquiry
CDCB186705 Rabbit COCH ORF clone (XM_002718124.2) Inquiry
CDCH383691 Mouse COCH ORF clone(NM_001198835.1) Inquiry
CDCL183664 Human COCH ORF clone(NM_004086.2) Inquiry
CDCL183665 Mouse COCH ORF clone(NM_007728.5) Inquiry
CDCR375341 Rat Coch ORF Clone(NM_001108710.1) Inquiry
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