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Recently, Zhang Feng's team from the Broad Institute published a research paper titled "Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery" online in PNAS. The study systematically explored human PNMA proteins and found that human cells secrete many PNMAs.
Toll-like receptor 4 (TLR4) is a central regulator of the body's innate immunity. It can mainly recognize bacterial lipopolysaccharide cell wall components and induce the release of cytokines. Recently, in a research report titled "RHBDL4-triggered downregulation of COPII adapter protein TMED7 suppresses TLR4-mediated inflammatory signaling" published in Nature Communications, scientists from the University of Cologne and other institutions found that the intramembrane protease RHBDL4 may be able to effectively prevent the body's excessive immune response. In the article, the researchers found that cleavage of cargo receptors by so-called intramembrane proteases reduces the localization of central immune receptors on the cell surface, thereby reducing the risk of an overreaction by the body's immune system.
