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MIF


Official Full Name
macrophage migration inhibitory factor
Organism
Homo sapiens
Gene ID
4282
Background
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Synonyms
GIF; GLIF; MMIF
Bio Chemical Class
Intramolecular oxidoreductase
Protein Sequence
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Open
Disease
Autoimmune disease, Diabetes mellitus, Postoperative inflammation, Thrombocytopenia
Approved Drug
0
Clinical Trial Drug
4 +
Discontinued Drug
0

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SHH084323 shRNA set against Rat Gif(NM_017162.2) Inquiry
SHH084287 shRNA set against Mouse Gif(NM_008118.3) Inquiry
SHH084305 shRNA set against Human GIF(NM_005142.2) Inquiry
SHH190001 shRNA set against Human MIF(NM_002415.1) Inquiry
SHH190019 shRNA set against Mouse Mif(NM_010798.2) Inquiry
SHH190037 shRNA set against Rat Mif(NM_031051.1) Inquiry
SHH301014 shRNA set against Human GIF (NM_005142.2) Inquiry
SHH301018 shRNA set against Mouse GIF (NM_008118.3) Inquiry
SHH301022 shRNA set against Rat GIF (NM_017162.2) Inquiry
SHH346028 shRNA set against Human MT3 (NM_005954.2) Inquiry
SHH346032 shRNA set against Mouse MT3 (NM_013603.2) Inquiry
SHH346036 shRNA set against Rat MT3 (NM_053968.3) Inquiry
SHL089886 shRNA set against Rat LOC690050(NM_001079531.1) Inquiry
SHW002641 shRNA set against Chicken MT3 (NM_001097538) Inquiry
SHW009733 shRNA set against Danio rerio MIF (NM_001043321) Inquiry
Cat.No. Product Name Price
RP00663 Recombinant Human MIF (C-His) Inquiry
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MiUTR1R-03916 MIF miRNA 3'UTR clone Inquiry
MiUTR1M-07118 MIF miRNA 3'UTR clone Inquiry
MiUTR1M-05030 GIF miRNA 3'UTR clone Inquiry
MiUTR1H-06495 MT3 miRNA 3'UTR clone Inquiry
MiUTR1H-06307 MIF miRNA 3'UTR clone Inquiry
MiUTR1H-04032 GIF miRNA 3'UTR clone Inquiry
CDFR012527 Rat Mif cDNA Clone(NM_031051.1) Inquiry
CDFR011214 Rat Gif cDNA Clone(NM_017162.2) Inquiry
CDCR244891 Mouse Gif ORF Clone(NM_008118.3) Inquiry
CDFH011839 Human MT3 cDNA Clone(NM_005954.2) Inquiry
CDFH011493 Human MIF cDNA Clone(NM_002415.1) Inquiry
CDFH007562 Human GIF cDNA Clone(NM_005142.2) Inquiry
MiUTR1R-02102 GIF miRNA 3'UTR clone Inquiry
CDCS412494 Human MT3 ORF Clone (BC013081) Inquiry
CDCS412119 Human GIF ORF Clone (BC037958) Inquiry
CDCR380677 Rat Mt3 ORF Clone(NM_053968.3) Inquiry
CDCR379549 Rat Mif ORF Clone(NM_031051.1) Inquiry
CDCR378228 Rat Gif ORF Clone(NM_017162.2) Inquiry
CDCR291697 Human MT3 ORF Clone(NM_005954.2) Inquiry
CDCR289687 Human GIF ORF Clone(NM_005142.2) Inquiry
CDCR252094 Mouse Mt3 ORF Clone(NM_013603.2) Inquiry
CDCL185348 Mouse MIF ORF clone(NM_010798.2) Inquiry
CDCL185347 Human MIF ORF clone(NM_002415.1) Inquiry
CDCB195539 Rabbit MT3 ORF clone (NM_001082220.2) Inquiry
CDCB194396 Rabbit MIF ORF clone (XM_002722561.2) Inquiry
CDCB184217 Rabbit GIF ORF clone (XM_002709184.2) Inquiry
CDCB171208 Danio rerio MIF ORF Clone (NM_001043321) Inquiry
CDCB164116 Chicken MT3 ORF Clone (NM_001097538) Inquiry
CDCS410781 Human MIF ORF Clone (BC000447) Inquiry
CDCB159897 Human GIF ORF clone (BC037958) Inquiry

Detailed Information

Recent Researches

Macrophage migration inhibitory factor (MIF) is a cytokine with multiple biological activities. It is the core of immune regulation and plays an important role in the inflammation and immune response of the body. In some diseases, the expression level of MIF has changed. Two polymorphic loci in its promoter affect its expression and are associated with susceptibility, severity and drug resistance in certain diseases.

The human MIF gene is located on chromosome 21q11.2, and the length of mRNA is about 0.8 kb. The MIF gene encodes 114 amino acids with a relative molecular mass of 12.5 x 103. About 90% of the MIF genes in mammals are homologous to fish, mites, parasites, certain plants, and cyanobacteria. The conservation of the MIF gene between species suggests that MIF proteins may have important biological functions. MIF is widely expressed in many tissues and cells, such as anterior pituitary cells, activated T lymphocytes, mononuclear macrophages, liver, kidney, and spleen.

Four gene polymorphisms have been found in the MIF gene, namely, SNP 173 (rs755622), +254 (rs2096525), +656 (rs2070766) and 1,794 CATT. Microsatellite polymorphisms are present in introns at +254 and +656 loci, as well as in promoters at 1,173 and 1,794 loci. Current studies have confirmed that MIF gene polymorphisms and increased MIF protein concentrations are associated with ulcerative colitis, psoriasis and tuberculosis. These diseases are often accompanied by inflammatory reactions, suggesting a key role of MIF in promoting the development and progression of these diseases.

Up to now, studies have shown that MIF gene mutations or polymorphisms are associated with arthritis, childhood nephropathy syndrome, asthma, autoimmune skin diseases, digestive system diseases (inflammatory bowel disease, gastrointestinal cancer and pancreatitis), prostatitis, and heart ischemia. In short, MIF proteins play an important role in acute and chronic inflammation and autoimmune diseases. Studying the functional polymorphism of its promoter will help to elucidate the mechanism of susceptibility, severity and drug resistance in different populations. Analysis of patients' MIF genotypes can help to categorize at-risk patients and identify which patients can conduct anti-MIF treatment strategies.

References:

  1. Cao Mengjiao, et al. Study on the relationship between MIF gene polymorphism and Helicobacter pylori infection and non-cardiac gastric cancer [J]. Journal of Gastroenterology and Hepatology, 2017, (6): 693-696.DOI: 10.3969/j.issn.1006-5709.2017.06.018.
  2. Zhou Ming, et al. Effects of MIF gene silencing on proliferation, apoptosis and ERK/RSK2 signaling pathway in hepatocellular carcinoma cell lines [J]. Chinese Journal of Modern Medicine, 2017, (19): 22-27.DOI: 10.3969/j.issn.1005-8982.2017.19.005.
  3. Qian lu, et al. MIF promoter region-173 polymorphism and coronary heart disease [J]. Journal of Medical Research, 2018, (4): 32-35.DOI: 10.11969/j.issn.1673-548X.2018.04.009.
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