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EPB49


Official Full Name
dematin actin binding protein
Organism
Homo sapiens
Gene ID
2039
Background
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Synonyms
DMTN; DMT; EPB49

Cat.No. Product Name Price
SHH286261 shRNA set against Human EPB49 (NM_001978.2) Inquiry
SHH286201 shRNA set against Mouse Epb4.9 (NM_013514.4) Inquiry
SHH286265 shRNA set against Rat EPB49 (NM_001108385.1) Inquiry
SHW013810 shRNA set against Danio rerio DMTN (NM_001201409) Inquiry
Cat.No. Product Name Price
CDFH005974 Human EPB49 cDNA Clone(NM_001114136.1) Inquiry
MiUTR3H-00648 EPB49 miRNA 3'UTR clone Inquiry
MiUTR3H-00647 EPB49 miRNA 3'UTR clone Inquiry
MiUTR3H-00646 EPB49 miRNA 3'UTR clone Inquiry
MiUTR1H-03253 EPB49 miRNA 3'UTR clone Inquiry
CDFR008006 Rat Epb49 cDNA Clone(NM_001108385.1) Inquiry
CDFH005978 Human EPB49 cDNA Clone(NM_001114139.1) Inquiry
CDFH005977 Human EPB49 cDNA Clone(NM_001114138.1) Inquiry
CDFH005976 Human EPB49 cDNA Clone(NM_001114137.1) Inquiry
MiUTR3H-00649 EPB49 miRNA 3'UTR clone Inquiry
MiUTR3H-00650 EPB49 miRNA 3'UTR clone Inquiry
CDCS407665 Human EPB49 ORF Clone (BC052805) Inquiry
CDCR375047 Rat Epb49 ORF Clone(NM_001108385.1) Inquiry
CDCR348043 Human EPB49 ORF Clone(NM_001114138.1) Inquiry
CDCR348039 Human EPB49 ORF Clone(NM_001114136.1) Inquiry
CDCR348037 Human EPB49 ORF Clone(NM_001114135.2) Inquiry
CDCR060678 Human EPB49 ORF clone (NM_001114139.1) Inquiry
CDCR060676 Human EPB49 ORF clone (NM_001114137.1) Inquiry
CDCB183233 Rabbit DMTN ORF clone (XM_008249885.1) Inquiry
CDCS407666 Human EPB49 ORF Clone (BC006318) Inquiry
CDCB175285 Danio rerio DMTN ORF Clone (NM_001201409) Inquiry
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