CD200R1

Official Full Name

CD200 receptor 1

Organism

Homo sapiens

Gene ID

131450

Background

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Synonyms

OX2R; MOX2R; CD200R; HCRTR2

Cat.No.	Product Name	Price
CSC-DC002715	Panoply™ Human CD200R1 Knockdown Stable Cell Line	Inquiry
CSC-SC002715	Panoply™ Human CD200R1 Over-expressing Stable Cell Line	Inquiry
CSC-RO0005	Human CD200R1 Stable Cell Line-CHO-K1	Inquiry
CLOE-0950	Human CD200R(His) HEK293 Cell Lysate	Inquiry
CLOE-0952	Human CD200R HEK293 Cell Lysate	Inquiry
CLOE-2823	Mouse Cd200r1 (His) HEK293 Cell Lysate	Inquiry
CLOE-2830	Mouse Cd200r1 (Fc) HEK293 Cell Lysate	Inquiry
CSC-RO02494	Human CD200R1 Stable Cell Line - HEK293	Inquiry
CSC-RO02495	Monkey CD200R1 Stable Cell Line - HEK293	Inquiry

Cat.No.	Product Name	Price
AD03320Z	Human CD200R1 adenoviral particles	Inquiry
LV08375L	human CD200R1 (NM_138940) lentivirus particles	Inquiry
LV08376L	human CD200R1 (NM_138806) lentivirus particles	Inquiry
LV08377L	human CD200R1 (NM_138939) lentivirus particles	Inquiry
LV08378L	human CD200R1 (NM_170780) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHG155377	shRNA set against Human CD200R1(NM_138939.2)	Inquiry
SHG155431	shRNA set against Human CD200R1(NM_170780.2)	Inquiry
SHH258649	shRNA set against Mouse CD200R1 (NM_021325.3)	Inquiry
SHG155323	shRNA set against Human CD200R1(NM_138940.2)	Inquiry
SHG155341	shRNA set against Human CD200R1(NM_138806.3)	Inquiry
SHG155359	shRNA set against Mouse Cd200r1(NM_021325.3)	Inquiry
SHH258645	shRNA set against Human CD200R1 (NM_138806.3)	Inquiry
SHH258653	shRNA set against Rat CD200R1 (NM_023953.1)	Inquiry
SHW002465	shRNA set against Chicken CD200R1 (NM_001079484)	Inquiry

Cat.No.	Product Name	Price
CDFG008109	Human CD200R1 cDNA Clone(NM_138806.3)	Inquiry
MiUTR1H-01854	CD200R1 miRNA 3'UTR clone	Inquiry
MiUTR1H-01853	CD200R1 miRNA 3'UTR clone	Inquiry
MiUTR1H-01852	CD200R1 miRNA 3'UTR clone	Inquiry
MiUTR1H-01851	CD200R1 miRNA 3'UTR clone	Inquiry
CDFR012210	Rat Cd200r1 cDNA Clone(NM_023953.1)	Inquiry
CDFG010356	Human CD200R1 cDNA Clone(NM_170780.2)	Inquiry
CDFG008303	Human CD200R1 cDNA Clone(NM_138940.2)	Inquiry
CDFG008300	Human CD200R1 cDNA Clone(NM_138939.2)	Inquiry
MiUTR1R-03964	CD200R1 miRNA 3'UTR clone	Inquiry
CDCR316962	Human CD200R1 ORF Clone(NM_138806.3)	Inquiry
CDCR043998	Human CD200R1 ORF clone (NM_138940.2)	Inquiry
CDCR043994	Human CD200R1 ORF clone (NM_170780.2)	Inquiry
CDCL183229	Mouse CD200R1 ORF clone(NM_021325.3)	Inquiry
MiUTR1M-02737	CD200R1 miRNA 3'UTR clone	Inquiry
CDCS416829	Human CD200R1 ORF Clone (BC069661)	Inquiry
CDCR379247	Rat Cd200r1 ORF Clone(NM_023953.1)	Inquiry
CDCR043996	Human CD200R1 ORF clone (NM_138939.2)	Inquiry
CDCB188783	Rabbit CD200R1 ORF clone (XM_008266944.1)	Inquiry
CDCB163940	Chicken CD200R1 ORF Clone (NM_001079484)	Inquiry

Detailed Information

CD200R, encoded by the CD200R1 gene, is a type I transmembrane protein belonging to the immunoglobulin superfamily. In the human genome, the CD200R1 gene encodes a receptor characterized by two extracellular Ig-like domains, a single transmembrane segment, and a relatively long cytoplasmic tail. Notably, the cytoplasmic tail lacks classical immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or activation motifs (ITAMs); instead, it recruits downstream signaling molecules via its unique terminal sequences, indicating a distinct signaling mechanism.

CD200R expression is highly restricted to myeloid cells, primarily macrophages, granulocytes, dendritic cells, and microglia, with little to no expression on adaptive immune cells such as T or B lymphocytes. This pattern strongly suggests that CD200R functions predominantly in negative regulation of innate immunity. Its only known endogenous ligand is CD200, a transmembrane glycoprotein with two Ig-like domains, broadly expressed in multiple tissue types including neurons, endothelial cells, and activated T cells. This receptor-ligand pair forms a classic immune checkpoint axis.

Biological Significance

CD200R is a critical inhibitory receptor that maintains immune homeostasis and tissue tolerance by transmitting negative signals to limit excessive myeloid cell–driven inflammation. Upon engagement with CD200, CD200R triggers intracellular events involving tyrosine phosphorylation and recruitment of adaptor proteins, ultimately leading to suppression of pro-inflammatory responses. This includes downregulation of key inflammatory mediators such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS).

The CD200-CD200R axis is therefore considered a myeloid cell–regulatory pathway, allowing tissue cells to convey a "self" or "non-threatening" signal to infiltrating myeloid cells during homeostasis or inflammation resolution, preventing collateral tissue damage. In the central nervous system, interaction between neuronal CD200 and microglial CD200R is crucial for maintaining microglial quiescence, preventing aberrant activation, and preserving neuroimmune homeostasis.

Figure 1. CD200:CD200R1 axis. (Kotwica-Mojzych K, et al., 2021)

Certain viruses, such as human herpesvirus 8, have evolved CD200 homologs that bind CD200R with similar affinity, hijacking this inhibitory pathway to suppress host antiviral immunity and facilitate persistent infection. This highlights CD200R as a key interface in host-pathogen co-evolution.

Clinical Relevance

CD200R is clinically significant due to its roles in tumor immune evasion and autoimmune/inflammatory diseases, making it an attractive therapeutic target. Many human cancers, including leukemia, melanoma, ovarian, and colorectal cancers, exhibit abnormally high CD200 expression. Engagement of CD200R on tumor-infiltrating myeloid cells delivers potent inhibitory signals, impairing antigen presentation, pro-inflammatory functions, and promoting differentiation into M2-like macrophages or tolerogenic dendritic cells, which suppress anti-tumor T cell responses and foster an immunosuppressive microenvironment.

Therapeutic strategies aim to block CD200-CD200R interactions to reinvigorate myeloid cell function and enhance anti-tumor immunity. Monoclonal antibodies targeting CD200 or CD200R have entered early clinical trials, with the goal of enhancing immune surveillance, potentially synergizing with existing checkpoint inhibitors.

In autoimmune and inflammatory diseases such as multiple sclerosis and rheumatoid arthritis, dysregulation of the CD200-CD200R axis contributes to pathological tissue damage. Enhancing this pathway using CD200R agonists or recombinant CD200-Fc fusion proteins could theoretically suppress overactive myeloid responses and mitigate disease progression. In neurodegenerative disorders such as Alzheimer's disease, reduced neuronal CD200 expression correlates with aberrant microglial activation, suggesting restoration of CD200R signaling may help control neuroinflammation.

Developing therapies targeting CD200R requires careful balancing of immune activation and autoimmunity risk, as well as a detailed understanding of its regulation across tissues and disease stages. Nevertheless, CD200R represents a critical myeloid immune checkpoint, opening new avenues for treating cancer and chronic inflammatory diseases.

References

Barclay AN, Wright GJ, Brooke G, Brown MH. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol. 2002;23(6):285–290.
Rijkers ES, de Ruiter T, Baridi A, Veninga H, Hoek RM, Meyaard L. The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes. Mol Immunol. 2008;45(4):1126–1135.
Kotwica-Mojzych K, Jodłowska-Jędrych B, Mojzych M. CD200:CD200R Interactions and Their Importance in Immunoregulation. Int J Mol Sci. 2021 Feb 5;22(4):1602.

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