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ARHGEF6

Official Full Name
Rac/Cdc42 guanine nucleotide exchange factor 6
Organism
Homo sapiens
GeneID
9459
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
Synonyms
PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX;

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