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ZAK

Official Full Name
mitogen-activated protein kinase kinase kinase 20
Organism
Mus musculus
GeneID
65964
Background
Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in MAPK cascade; embryonic digit morphogenesis; and protein phosphorylation. Acts upstream of or within cytoskeleton organization. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Map3k20; MRK; Zak; MLTK; HCCS-4; MLTKbeta; MLTKalpha; B230120H23Rik;

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