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VPS33A


Official Full Name
VPS33A core subunit of CORVET and HOPS complexes
Organism
Homo sapiens
Gene ID
65082
Background
This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017]
Synonyms
MPSPS

Cat.No. Product Name Price
SHH444928 shRNA set against Human VPS33A (NM_022916.4) Inquiry
SHH444932 shRNA set against Mouse VPS33A (NM_029929.3) Inquiry
SHH444936 shRNA set against Rat VPS33A (NM_022961.3) Inquiry
SHL127542 shRNA set against Rat Vps33a(NM_022961.3) Inquiry
SHL127596 shRNA set against Human VPS33A(NM_022916.4) Inquiry
SHW011671 shRNA set against Danio rerio VPS33A (NM_001099973) Inquiry
Cat.No. Product Name Price
CDCH403712 Mouse VPS33A ORF clone(NM_029929.3) Inquiry
CDFG004042 Human VPS33A cDNA Clone(NM_022916.4) Inquiry
CDFR012184 Rat Vps33a cDNA Clone(NM_022961.3) Inquiry
MiUTR1H-11151 VPS33A miRNA 3'UTR clone Inquiry
MiUTR1R-08541 VPS33A miRNA 3'UTR clone Inquiry
CDCB173146 Danio rerio VPS33A ORF Clone (NM_001099973) Inquiry
CDCB191163 Rabbit VPS33A ORF clone (XM_002722732.2) Inquiry
CDCR308352 Human VPS33A ORF Clone(NM_022916.4) Inquiry
CDCR379231 Rat Vps33a ORF Clone(NM_022961.3) Inquiry
CDCS415581 Human VPS33A ORF Clone (BC016617) Inquiry
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