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USP18


Official Full Name
ubiquitin specific peptidase 18
Organism
Homo sapiens
Gene ID
11274
Background
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Synonyms
ISG43; UBP43; PTORCH2

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SHL117484 shRNA set against Human USP18(NM_017414.3) Inquiry
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CDCR251384 Mouse Usp18 ORF Clone(NM_011909.2) Inquiry
CDCR370210 Rat Usp18 ORF Clone(NM_001014058.1) Inquiry
CDCS414386 Human USP18 ORF Clone (BC014896) Inquiry
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