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TOP2B


Official Full Name
DNA topoisomerase II beta
Organism
Homo sapiens
Gene ID
7155
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Synonyms
BILU; TOPIIB; top2beta

Cat.No. Product Name Price
SHH432876 shRNA set against Mouse Top2b (NM_009409.2) Inquiry
SHW005582 shRNA set against Chicken TOP2B (NM_205082) Inquiry
SHH432872 shRNA set against Human Top2b (NM_001068.2) Inquiry
SHL087750 shRNA set against Human TOP2B(NM_001068.2) Inquiry
SHL087798 shRNA set against Mouse Top2b(NM_009409.2) Inquiry
SHW010103 shRNA set against Danio rerio TOP2B (NM_001045191) Inquiry
Cat.No. Product Name Price
CDCB167057 Chicken TOP2B ORF Clone (NM_205082) Inquiry
CDCB187017 Rabbit TOP2B ORF clone (XM_008266069.1) Inquiry
CDFH020116 Human TOP2B cDNA Clone(NM_001068.2) Inquiry
MiUTR1H-10643 TOP2B miRNA 3'UTR clone Inquiry
MiUTR1M-12050 TOP2B miRNA 3'UTR clone Inquiry
SKO0854 TOP2B Validated sgRNA vector Inquiry
CDCB171578 Danio rerio TOP2B ORF Clone (NM_001045191) Inquiry
CDCG003175 Rat TOP2B ORF clone(NM_001100858.1) Inquiry
CDCH094010 Mouse Top2b ORF clone (NM_009409.2) Inquiry
CDCR344957 Human TOP2B ORF Clone(NM_001068.2) Inquiry
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